Chinese Journal of Tissue Engineering Research ›› 2013, Vol. 17 ›› Issue (28): 5216-5222.doi: 10.3969/j.issn.2095-4344.2013.28.019
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Xiao Pin1, 2, Pang Yi-hui3, Peng Peng1, Bo Hai1
Online:
2013-07-09
Published:
2013-07-09
Contact:
Bo Hai, M.D., Lecturer, Department of Military Training Medicine, Logistics University of Chinese People’s Armed Police Force, Tianjin 300162, China
bohaixd@126.com
About author:
Xiao Pin, Department of Pharmacy, Jiangxi Provincial Corps Hospital of Chinese People’s Armed Police Force, Nanchang 330001, Jiangxi Province, China; Department of Pharmacy, Jiangxi Provincial Corps Hospital of Chinese People’s Armed Police Force, Nanchang 330001, Jiangxi Province, China
zpchen_5500@126.com
Supported by:
Youth Foundation of Application Basis and Front Technology Research of Tianjin, No. 12JCQNJC07900*;
Science and Technology Research Foundation of Logistics University of Chinese People’s Armed Police Force, No. WYB201106*
CLC Number:
Xiao Pin, Pang Yi-hui, Peng Peng, Bo Hai. Alpha-lipoic acid inhibits mitochondrial oxidative stress in the rat skeletal muscle with chronic hypoxia exposure[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(28): 5216-5222.
单纯低氧组大鼠骨骼肌线粒体ST3,RCR,ADP/O,ATP合成活力、膜电位显著低于常氧对照组 (P < 0.05),而大鼠骨骼肌线粒体ST4显著高于常氧对照组(P < 0.05)。与单纯低氧组比较,单纯低氧+α-硫辛酸组大鼠骨骼肌线粒体ST3,RCR,ADP/O,ATP合成活力、膜电位明显升高(P < 0.05),ST4显著降低 (P < 0.05)。 2.4 各组大鼠骨骼肌SIRT3 mRNA和蛋白表达的变化 单纯低氧组大鼠骨骼肌SIRT3 mRNA和蛋白表达均显著低于常氧对照组(P < 0.05)。与单纯低氧组比较,单纯低氧+α-硫辛酸组大鼠骨骼肌SIRT3 mRNA和蛋白表达明显升高(P < 0.05,P < 0.01),见图1。"
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